Manuel Perucho - Premios Atlántico de Investigación del Cáncer

PREMIOS ATLÁNTICO
DE INVESTIGACIÓN DEL CÁNCER
2003 – Universidad de Las Palmas
Clausura Titulo de Experto en Oncología Molecular

MANUEL PERUCHO
Albacete, 1948

Investigador del Burnham Institute
La Jolla, California

Publicaciones Recientes:

1: Ionov Y, Nowak N, Perucho M, Markowitz S, Cowell JK. Related Articles, Links
Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability.
Oncogene. 2004 Jan 22;23(3):639-45.

2: Suzuki K, Ohnami S, Tanabe C, Sasaki H, Yasuda J, Katai H, Yoshimura K, Terada M, Perucho M, Yoshida T.
The genomic damage estimated by arbitrarily primed PCR DNA fingerprinting is useful for the prognosis of gastric cancer.
Gastroenterology. 2003 Nov;125(5):1330-40.

3: Yamashita K, Dai T, Dai Y, Yamamoto F, Perucho M.
Genetics supersedes epigenetics in colon cancer phenotype.
Cancer Cell. 2003 Aug;4(2):121-31.

4: Perucho M.
Tumors with microsatellite instability: many mutations, targets and paradoxes.
Oncogene. 2003 Apr 17;22(15):2223-5.

5: Yamamoto H, Imai K, Perucho M. Related Articles, Links
Gastrointestinal cancer of the microsatellite mutator phenotype pathway.
J Gastroenterol. 2002;37(3):153-63. Review.

6: Suzuki K, Dai T, Suzuki I, Dai Y, Yamashita K, Perucho M.
Low mutation incidence in polymorphic noncoding short mononucleotide repeats in gastrointestinal cancer of the microsatellite mutator phenotype pathway.
Cancer Res. 2002 Apr 1;62(7):1961-5.

7: Baranovskaya S, Soto JL, Perucho M, Malkhosyan SR.
Functional significance of concomitant inactivation of hMLH1 and hMSH6 in tumor cells of the microsatellite mutator phenotype.
Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15107-12. Epub 2001 Dec 11.

8: Odero MD, Soto JL, Matutes E, Martin-Subero JI, Zudaire I, Rao PH, Cigudosa JC, Ardanaz MT, Chaganti RS, Perucho M, Calasanz MJ.
Comparative genomic hybridization and amplotyping by arbitrarily primed PCR in stage A B-CLL.
Cancer Genet Cytogenet. 2001 Oct 1;130(1):8-13.

9: Ohmiya N, Matsumoto S, Yamamoto H, Baranovskaya S, Malkhosyan SR, Perucho M.
Germline and somatic mutations in hMSH6 and hMSH3 in gastrointestinal cancers of the microsatellite mutator phenotype.
Gene. 2001 Jul 11;272(1-2):301-13.

10: Yamamoto F, Yamamoto M, Soto JL, Kojima E, Wang EN, Perucho M, Sekiya T, Yamanaka H.
Notl-Msell methylation-sensitive amplied fragment length polymorhism for DNA methylation analysis of human cancers.
Electrophoresis. 2001 Jun;22(10):1946-56.

11: Yamamoto H, Yamashita K, Perucho M.
Somatic mutation of the beta2-microglobulin gene associates with unfavorable prognosis in gastrointestinal cancer of the microsatellite mutator phenotype.
Gastroenterology. 2001 May;120(6):1565-7.

12: Yamamoto H, Itoh F, Nakamura H, Fukushima H, Sasaki S, Perucho M, Imai K.
Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability.
Cancer Res. 2001 Apr 1;61(7):3139-44.

13: Fang W, Piao Z, Buyse IM, Simon D, Sheu JC, Perucho M, Huang S.
Preferential loss of a polymorphic RIZ allele in human hepatocellular carcinoma.
Br J Cancer. 2001 Mar 23;84(6):743-7.

14: Schwartz S Jr, Perucho M.
Somatic mutations in mitochondrial DNA do not associate with nuclear microsatellite instability in gastrointestinal cancer.
Gastroenterology. 2000 Dec;119(6):1806-8. No abstract available.

15: Piao Z, Lee KS, Kim H, Perucho M, Malkhosyan S.
Identification of novel deletion regions on chromosome arms 2q and 6p in breast carcinomas by amplotype analysis.
Genes Chromosomes Cancer. 2001 Feb;30(2):113-22.

16: Piao Z, Fang W, Malkhosyan S, Kim H, Horii A, Perucho M, Huang S. Frequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability.
Cancer Res. 2000 Sep 1;60(17):4701-4.

17: Ionov Y, Yamamoto H, Krajewski S, Reed JC, Perucho M. Related Articles, Links
Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution.
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10872-7.

18: Perucho M.
Genetic and epigenetic modification of MLH1.
Am J Pathol. 2000 Sep;157(3):1052-3. No abstract available.

19: Malkhosyan SR, Yamamoto H, Piao Z, Perucho M. Related Articles, Links
Late onset and high incidence of colon cancer of the mutator phenotype with hypermethylated hMLH1 gene in women.
Gastroenterology. 2000 Aug;119(2):598. No abstract available.

20: Yamada T, Kohno T, Navarro JM, Ohwada S, Perucho M, Yokota J
Frequent chromosome 8q gains in human small cell lung carcinoma detected by arbitrarily primed-PCR genomic fingerprinting.
Cancer Genet Cytogenet. 2000 Jul 1;120(1):11-7.

21, Perucho M.
Microsatellite instability: the mutator that mutates the other mutator.
Nat Med. 1996 Jun;2(6):630-1.

22: Perucho M, Peinado MA, Ionov Y, Casares S, Malkhosyan S, Stanbridge E. Defects in replication fidelity of simple repeated sequences reveal a new mutator mechanism for oncogenesis.
Cold Spring Harb Symp Quant Biol. 1994;59:339-48. Review.

23. Rampino N, Yamamoto H, Ionov Y, Li Y, Sawai H, Reed JC, Perucho M
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.
Science. 1997 Feb 14;275(5302):967-9.

24. Malkhosyan S, Rampino N, Yamamoto H, Perucho M.
Frameshift mutator mutations.
Nature. 1996 Aug 8;382(6591):499-500.

25: Perucho M. Related Articles, Links
Microsatellite instability: the mutator that mutates the other mutator.
Nat Med. 1996 Jun;2(6):630-1.

26. Shibata D, Peinado MA, Ionov Y, Malkhosyan S, Perucho M. Related Articles, Links
Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation.
Nat Genet. 1994 Mar;6(3):273-81.

27: Perucho M, Peinado MA, Ionov Y, Casares S, Malkhosyan S, Stanbridge E. Defects in replication fidelity of simple repeated sequences reveal a new mutator mechanism for oncogenesis.
Cold Spring Harb Symp Quant Biol. 1994;59:339-48. Review.

28: Shibata D, Schaeffer J, Li ZH, Capella G, Perucho M.
Genetic heterogeneity of the c-K-ras locus in colorectal adenomas but not in adenocarcinomas.
J Natl Cancer Inst. 1993 Jul 7;85(13):1058-63.

29. Ionov Y, Peinado MA, Malkhosyan S, Shibata D, Perucho M.
Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis.
Nature. 1993 Jun 10;363(6429):558-61.

30: Peinado MA, Malkhosyan S, Velazquez A, Perucho M.
Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction.
Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10065-9.

31. Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M. Related Articles, Links
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes.
Cell. 1988 May 20;53(4):549-54.

32. Forrester K, Almoguera C, Han K, Grizzle WE, Perucho M.
Detection of high incidence of K-ras oncogenes during human colon tumorigenesis.
Nature. 1987 May 28-Jun 3;327(6120):298-303.

33. Winter E, Yamamoto F, Almoguera C, Perucho M.
A method to detect and characterize point mutations in transcribed genes: amplification and overexpression of the mutant c-Ki-ras allele in human tumor cells.
Proc Natl Acad Sci U S A. 1985 Nov;82(22):7575-9.

34: Nakano H, Yamamoto F, Neville C, Evans D, Mizuno T, Perucho M. Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes.
Proc Natl Acad Sci U S A. 1984 Jan;81(1):71-5.

35: Shimizu K, Goldfarb M, Suard Y, Perucho M, Li Y, Kamata T, Feramisco J, Stavnezer E, Fogh J, Wigler MH.
Three human transforming genes are related to the viral ras oncogenes.
Proc Natl Acad Sci U S A. 1983 Apr;80(8):2112-6.

36: Shimizu K, Goldfarb M, Perucho M, Wigler M.
Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line.
Proc Natl Acad Sci U S A. 1983 Jan;80(2):383-7.

37: Goldfarb M, Shimizu K, Perucho M, Wigler M.
Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells.
Nature. 1982 Apr 1;296(5856):404-9.

38: Perucho M, Molgaard HV, Ruiz-Carrillo A.
Enrichment of histone H5-synthesizing polysomes by indirect immunoadsorption. Purification of H5 mRNA.
J Biol Chem. 1982 Jan 25;257(2):958-63.

88: Perucho M, Goldfarb M, Shimizu K, Lama C, Fogh J, Wigler M.
Human-tumor-derived cell lines contain common and different transforming genes.
Cell. 1981 Dec;27(3 Pt 2):467-76.

89: Wigler M, Levy D, Perucho M.
The somatic replication of DNA methylation.
Cell. 1981 Apr;24(1):33-40.

90: Perucho M, Wigler M.
Linkage and expression of foreign DNA in cultured animal cells.
Cold Spring Harb Symp Quant Biol. 1981;45 Pt 2:829-38.

91: Perucho M, Hanahan D, Wigler M.
Genetic and physical linkage of exogenous sequences in transformed cells.
Cell. 1980 Nov;22(1 Pt 1):309-17.

92: Wigler M, Perucho M, Kurtz D, Dana S, Pellicer A, Axel R, Silverstein S Transformation of mammalian cells with an amplifiable dominant-acting gene.
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3567-70.

93: Perucho M, Hanahan D, Lipsich L, Wigler M.
Isolation of the chicken thymidine kinase gene by plasmid rescue.
Nature. 1980 May 22;285(5762):207-10.

95: Molgaard HV, Perucho M, Ruiz-Carrillo A.
Histone H5 messenger RNA is polyadenylated.
Nature. 1980 Jan 31;283(5746):502-4.